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The contribution of demyelination to axonal loss in multiple sclerosis

Abstract:

The traditional notion that multiple sclerosis is a primary demyelinating disease has led to a plaque-centred view of both aetiology and the pathogenesis of disease progression. The presence of axonal loss has received increasing recognition. However, the relative roles of demyelination and axonal loss have not been fully clarified in multiple sclerosis nor have their possible interrelationships been elucidated. Post-mortem material from the cerebrum, brainstem and spinal cord of 55 multiple ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awl074

Authors


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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
More by this author
Institution:
Queen's Medical Centre, University Hospital NHS Trust, Nottingham, UK
Department:
Department of Neurology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
More by this author
Institution:
"University of Oxford", "Oxford Radcliffe NHS Trust"
Department:
Department of Neuropathology
Role:
Author
More from this funder
Funding agency for:
G. C. DeLuca
Multiple Sclerosis Society of Canada More from this funder
Multiple Sclerosis Society of Great Britain and Northern Ireland More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
129
Issue:
6
Pages:
1507-1516
Publication date:
2006-01-01
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
URN:
uuid:22fb9f09-7513-4a23-be08-5192130dba2e
Local pid:
ora:4819

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