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Biomarkers of oxidative stress following continuous positive airway pressure withdrawal: data from two randomised trials.

Abstract:

There is conflicting evidence whether intermittent hypoxia in obstructive sleep apnoea (OSA) influences oxidative stress. We hypothesised that withdrawal of continuous positive airway pressure (CPAP) from patients with OSA would raise markers of oxidative stress.59 patients with CPAP-treated moderate-to-severe OSA (oxygen desaturation index (ODI) >20 events·h(-1)) were randomised 1:1 to either stay on CPAP (n=30) or change to sham CPAP (n=29) for 2 weeks. Using samples from two similar stu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1183/09031936.00023215

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More from this funder
Name:
Swiss National Science Foundation
Publisher:
European Respiratory Society
Journal:
European respiratory journal More from this journal
Volume:
46
Issue:
4
Pages:
1065-1071
Publication date:
2015-10-01
DOI:
EISSN:
1399-3003
ISSN:
0903-1936
Language:
English
Pubs id:
pubs:525512
UUID:
uuid:22f99c28-6fd6-40d7-9906-a4c6eb585dcb
Local pid:
pubs:525512
Source identifiers:
525512
Deposit date:
2015-10-14

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