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Journal article

The use of dioxygen by HIF prolyl hydroxylase (PHD1).

Abstract:
The hypoxic response in animals is mediated by hydroxylation of proline residues in the alpha-subunit of hypoxia inducible factor (HIF). Hydroxylation is catalysed by prolyl-4-hydroxylases (PHD isozymes in humans) which are iron(II) and 2-oxoglutarate dependent oxygenases. Mutation of the arginine proposed to bind 2-oxoglutarate and of the 2His-1-carboxylate iron(II) binding motif in PHD1 dramatically reduces its activity. The source of the oxygen of the product alcohol is (>95%) dioxygen.
Publication status:
Published

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Journal:
Bioorganic and medicinal chemistry letters More from this journal
Volume:
12
Issue:
12
Pages:
1547-1550
Publication date:
2002-06-01
DOI:
EISSN:
1464-3405
ISSN:
0960-894X
Language:
English
Keywords:
Pubs id:
pubs:25136
UUID:
uuid:22f40c85-5058-4718-9bbe-6dd6ac1267f3
Local pid:
pubs:25136
Source identifiers:
25136
Deposit date:
2012-12-19

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