Journal article icon

Journal article

Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination.

Abstract:

Although present in both humans and chimpanzees, recombination hotspots, at which meiotic crossover events cluster, differ markedly in their genomic location between the species. We report that a 13-base pair sequence motif previously associated with the activity of 40% of human hotspots does not function in chimpanzees and is being removed by self-destructive drive in the human lineage. Multiple lines of evidence suggest that the rapidly evolving zinc-finger protein PRDM9 binds to this motif...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1126/science.1182363

Authors


Journal:
Science (New York, N.Y.)
Volume:
327
Issue:
5967
Pages:
876-879
Publication date:
2010-02-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Language:
English
Keywords:
Pubs id:
pubs:88385
UUID:
uuid:22f25d0d-bbc9-4725-ab06-c948362c306a
Local pid:
pubs:88385
Source identifiers:
88385
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP