Journal article
CD73 is dispensable for the regulation of inflationary CD8+ T-cells after murine cytomegalovirus infection and adenovirus immunisation
- Abstract:
-
The ecto-5'-nucleotidase (CD73) is expressed by T-cell subsets, myeloid derived suppressive cells and endothelial cells. It works in conjunction with CD39 to regulate the formation and degradation of adenosine in vivo. Adenosine has previously been shown to suppress the proliferation and cytokine secretion of T-cells and recent evidence suggests that inhibition of CD73 has the potential to enhance T-cell directed therapies. Here we utilised a CD73 knockout mouse model to assess the suppressiv...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 9
- Issue:
- 12
- Pages:
- ARTN e114323
- Publication date:
- 2014-12-09
- Acceptance date:
- 2014-11-06
- DOI:
- EISSN:
-
1932-6203
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:22ef1cbf-6404-4a78-bd7c-cb3d7bb9110c
- Local pid:
- pubs:493327
- Source identifiers:
-
493327
- Deposit date:
- 2014-12-20
Terms of use
- Copyright holder:
- Sims et al
- Copyright date:
- 2014
- Notes:
- Copyright: © 2014 Sims et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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