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Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion.

Abstract:

The KCl cotransporter (KCC) is a major determinant of osmotic homeostasis and plays an emerging role in tumor biology. This study stresses the important role of KCC4 in tumor malignant behavior. Real-time reverse transcription-PCR on samples collected by laser microdissection and immunofluorescent stainings with different KCC isoform antibodies indicate that KCC4 is abundant in metastatic cervical and ovarian cancer tissues. Insulin-like growth factor I (IGF-I) and epidermal growth factor (EG...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Cancer research More from this journal
Volume:
69
Issue:
22
Pages:
8585-8593
Publication date:
2009-11-01
DOI:
EISSN:
1538-7445
ISSN:
0008-5472

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