Motor protein-dependent membrane trafficking of KCl cotransporter-4 is important for cancer cell invasion.

Journal article

The KCl cotransporter (KCC) is a major determinant of osmotic homeostasis and plays an emerging role in tumor biology. This study stresses the important role of KCC4 in tumor malignant behavior. Real-time reverse transcription-PCR on samples collected by laser microdissection and immunofluorescent stainings with different KCC isoform antibodies indicate that KCC4 is abundant in metastatic cervical and ovarian cancer tissues. Insulin-like growth factor I (IGF-I) and epidermal growth factor (EG...

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Authors: Chen, Y; Chou, C; Wilkins, R; Ellory, J; Mount, D

• Publication status: Published
• Journal: Cancer research
• Volume: 69
• Issue: 22
• Pages: 8585-8593
• Publication date: 2009-11-01
• DOI: 10.1158/0008-5472.can-09-2284
• EISSN: 1538-7445
• ISSN: 0008-5472
• Language: English
• Keywords: Female; Fluorescent Antibody Technique; Uterine Cervical Neoplasms; Microdissection; Cell Membrane; Symporters; RNA, Small Interfering; Neoplasm Invasiveness; Reverse Transcriptase Polymerase Chain Reaction; Adult; Insulin-Like Growth Factor I; Lasers; Protein Transport; Aged; Cell Line, Tumor; Humans; Epidermal Growth Factor; Ovarian Neoplasms; Middle Aged; Molecular Motor Proteins