Serum elastin-derived peptides in age-related macular degeneration.
PURPOSE: Dysregulation of the extracellular matrix (ECM) plays an important role in the pathogenesis of age-related macular degeneration (AMD). Elastin is a fibrous protein constituent of the ECM, degradation of which may be detected by the presence of serum elastin-derived peptides (S-EDPs) in circulation. This study was undertaken to estimate levels of S-EDPs in patients with AMD compared with age-matched control subjects. METHODS: Fifty-six patients with AMD were classified into two group...Expand abstract
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