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Thesis

Cellular studies on the role of OGFOD1, a 2-oxoglutarate-dependent dioxygenase

Abstract:

2-Oxoglutarate (2-OG) and iron (Fe2+) dependent Oxygenase Domain containing protein 1 (OGFOD1) is an evolutionarily conserved prolyl hydroxylase enzyme in mammals, invertebrates (Sud1 in D. melanogaster) and yeast (TPA1 in S. cerevisiae and Ofd1 in S. pombe). This enzyme modifies a residue corresponding to Proline-62 in humans of the small ribosome protein S23 (RPS23) that occupies a critical site within the decoding centre of the eukaryotic ribosome. A number of cellular phenot...

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Division:
MSD
Department:
Doctoral Training Centre - MSD
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Ludwig Institute for Cancer Research More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Keywords:
Subjects:
UUID:
uuid:22eabdfb-b0f1-43be-b802-4d7c7dc161d5
Deposit date:
2018-08-02

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