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Class II-restricted IgG2ab-specific T cells recognize a signal-minus form of the V-CH3b antigen.

Abstract:

To study the question when and where self peptides become associated with major histocompatibility complex class II molecules for tolerance induction, we recently developed a system in which the intracellular site(s) of antigen expression could be manipulated using gene cloning techniques. We previously constructed a truncated IgGa gene comprising a variable (V) domain and the CH3 domain (not including the membrane exons) from the IgG2ab heavy (H) chain. The secreted form of the V-CH3b protei...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830210613

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
European journal of immunology
Volume:
21
Issue:
6
Pages:
1411-1417
Publication date:
1991-06-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:22ea96b3-8f7c-4f89-b70c-f239c16fe914
Source identifiers:
9174
Local pid:
pubs:9174

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