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Coordination of vasomotor responses by the endothelium.

Abstract:

Increases in the diameter of small resistance arteries and arterioles occur secondary to processes that can be dependent or independent of changes in membrane potential. Hyperpolarization reduces the opening of voltage-gated calcium channels and thereby the stimulus for contraction of these resistance vessels. The stimulus for smooth muscle cell (SMC) hyperpolarization can occur directly via opening K(+)-channels expressed within those cells, but can also occur in response to stimulation of e...

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Publication status:
Published

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Publisher copy:
10.1253/circj.cj-09-0879

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Journal:
Circulation journal : official journal of the Japanese Circulation Society
Volume:
74
Issue:
2
Pages:
226-232
Publication date:
2010-02-05
DOI:
EISSN:
1347-4820
ISSN:
1346-9843
URN:
uuid:22e98634-548d-43c2-bb69-cdcc344c6374
Source identifiers:
106280
Local pid:
pubs:106280

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