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Journal article

Peripheral DNA methylation, cognitive decline and brain ageing: Pilot findings from the Whitehall II Imaging Study

Abstract:

Background

DNA methylation (DNAm) has been linked with the pathophysiology of brain aging, cognitive impairment and dementia.

Methods

The present study investigated the association between blood genome-wide DNAm profiles, cognitive dysfunction and brain magnetic resonance imaging (MRI) measures in 48 participants of the Whitehall II imaging sub-study.

Results

We identified eight differentially methylated regions (DMRs) associated with cognitive imp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.2217/epi-2017-0132

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
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Oxfordshire Health Services Research Committee More from this funder
National Institute of Health Research More from this funder
Oxford University Clinical Academic Graduate School More from this funder
Gordon Edward Small’s Charitable Trust More from this funder
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Publisher:
Future Medicine Publisher's website
Journal:
Epigenomics Journal website
Volume:
10
Issue:
5
Pages:
585–595
Publication date:
2018-04-25
Acceptance date:
2017-12-19
DOI:
EISSN:
1750-192X
ISSN:
1750-1911
Source identifiers:
812291
Keywords:
Pubs id:
pubs:812291
UUID:
uuid:22e00e0d-b1e2-49a4-a76d-b4e791c89f2f
Local pid:
pubs:812291
Deposit date:
2017-12-21

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