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Journal article

Peripheral DNA methylation, cognitive decline and brain ageing: Pilot findings from the Whitehall II Imaging Study

Abstract:

Background

DNA methylation (DNAm) has been linked with the pathophysiology of brain aging, cognitive impairment and dementia.

Methods

The present study investigated the association between blood genome-wide DNAm profiles, cognitive dysfunction and brain magnetic resonance imaging (MRI) measures in 48 participants of the Whitehall II imaging sub-study.

Results

We identified eight differentially methylated regions (DMRs) associated with cognitive imp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.2217/epi-2017-0132

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
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Name:
Medical Research Council
Grant:
MR/N027973/1
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Name:
HDH Wills 1965 charitable trust
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Name:
Gordon Edward Small’s Charitable Trust
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Name:
Oxford University Clinical Academic Graduate School
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Name:
National Institute of Health Research
Publisher:
Future Medicine
Journal:
Epigenomics More from this journal
Volume:
10
Issue:
5
Pages:
585–595
Publication date:
2018-04-25
Acceptance date:
2017-12-19
DOI:
EISSN:
1750-192X
ISSN:
1750-1911
Keywords:
Pubs id:
pubs:812291
UUID:
uuid:22e00e0d-b1e2-49a4-a76d-b4e791c89f2f
Local pid:
pubs:812291
Source identifiers:
812291
Deposit date:
2017-12-21

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