Journal article
Peripheral DNA methylation, cognitive decline and brain ageing: Pilot findings from the Whitehall II Imaging Study
- Abstract:
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Background
DNA methylation (DNAm) has been linked with the pathophysiology of brain aging, cognitive impairment and dementia.
Methods
The present study investigated the association between blood genome-wide DNAm profiles, cognitive dysfunction and brain magnetic resonance imaging (MRI) measures in 48 participants of the Whitehall II imaging sub-study.
Results
We identified eight differentially methylated regions (DMRs) associated with cognitive imp...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
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(Version of record, pdf, 2.0MB)
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- Publisher copy:
- 10.2217/epi-2017-0132
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Authors
Funding
Oxfordshire Health Services Research Committee
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National Institute of Health Research
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Oxford University Clinical Academic Graduate School
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Gordon Edward Small’s Charitable Trust
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Bibliographic Details
- Publisher:
- Future Medicine Publisher's website
- Journal:
- Epigenomics Journal website
- Volume:
- 10
- Issue:
- 5
- Pages:
- 585–595
- Publication date:
- 2018-04-25
- Acceptance date:
- 2017-12-19
- DOI:
- EISSN:
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1750-192X
- ISSN:
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1750-1911
- Source identifiers:
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812291
Item Description
- Keywords:
- Pubs id:
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pubs:812291
- UUID:
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uuid:22e00e0d-b1e2-49a4-a76d-b4e791c89f2f
- Local pid:
- pubs:812291
- Deposit date:
- 2017-12-21
Terms of use
- Copyright holder:
- Leonidas Chouliaras
- Copyright date:
- 2018
- Notes:
- © Leonidas Chouliaras. This work is licensed under the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
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