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Palladium mediated protein modification

Abstract:
Benign C–C bond formation at various sites in cell-surface channels has been achieved through Suzuki–Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms
Publication status:
Published

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Publisher copy:
10.1021/ja209352s

Authors


Spicer, CD More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Union Chimique Belge More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Volume:
134
Issue:
2
Pages:
800–803
Publication date:
2013-04-07
DOI:
ISSN:
0065-7727
URN:
uuid:22dfcdfb-406e-4884-8e52-be945aa7b0e0
Source identifiers:
436855
Local pid:
pubs:436855

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