Conference
Palladium mediated protein modification
- Abstract:
- Benign C–C bond formation at various sites in cell-surface channels has been achieved through Suzuki–Miyaura coupling of genetically positioned unnatural amino acids containing aryl halide side chains. This enabled site-selective cell surface manipulation of Escherichia coli; the phosphine-free catalyst caused no cell death at required Pd loadings, suggesting future in vivo application of catalytic metal-mediated bond formation in more complex organisms
- Publication status:
- Published
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- Publisher copy:
- 10.1021/ja209352s
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Authors
Funding
Union Chimique Belge
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Biotechnology and Biological Sciences Research Council
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Bibliographic Details
- Volume:
- 134
- Issue:
- 2
- Pages:
- 800–803
- Publication date:
- 2013-04-07
- DOI:
- ISSN:
-
0065-7727
- URN:
-
uuid:22dfcdfb-406e-4884-8e52-be945aa7b0e0
- Source identifiers:
-
436855
- Local pid:
- pubs:436855
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2013
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