- Abstract:
-
One of the hallmarks of male germ cell development is the formation of a specialized secretory organelle, the acrosome. This process can be pharmacologically disturbed in C57BL/6 mice, and thus infertility can be induced, by small molecular sugar-like compounds (alkylated imino sugars). Here the biochemical basis of this effect has been investigated. Our findings suggest that in vivo alkylated imino sugars primarily interact with the non-lysosomal glucosylceramidase. This enzyme cleaves gluco...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m702387200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 282
- Issue:
- 45
- Pages:
- 32655-32664
- Publication date:
- 2007-11-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:22db4cb6-9886-4a28-b7e0-ef196f21beb9
- Source identifiers:
-
101064
- Local pid:
- pubs:101064
- Language:
- English
- Keywords:
- Copyright date:
- 2007
Journal article
Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.
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