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Journal article

Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.

Abstract:

One of the hallmarks of male germ cell development is the formation of a specialized secretory organelle, the acrosome. This process can be pharmacologically disturbed in C57BL/6 mice, and thus infertility can be induced, by small molecular sugar-like compounds (alkylated imino sugars). Here the biochemical basis of this effect has been investigated. Our findings suggest that in vivo alkylated imino sugars primarily interact with the non-lysosomal glucosylceramidase. This enzyme cleaves gluco...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m702387200

Authors


Walden, CM More by this author
Sandhoff, R More by this author
Chuang, CC More by this author
Butters, TD More by this author
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Journal:
The Journal of biological chemistry
Volume:
282
Issue:
45
Pages:
32655-32664
Publication date:
2007-11-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:22db4cb6-9886-4a28-b7e0-ef196f21beb9
Source identifiers:
101064
Local pid:
pubs:101064

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