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Inositol polyphosphate 4-phosphatase type I regulates cell growth downstream of transcription factor GATA-1.

Abstract:

Megakaryocytes lacking transcription factor GATA-1 fail to complete maturation in vivo and hyperproliferate. To define how GATA-1 regulates megakaryocyte cell growth we searched for mRNA transcripts expressed in primary wild-type, but not GATA-1(-), megakaryocytes. One differentially expressed transcript encodes inositol polyphosphate 4-phosphatase type I (4-Ptase I). This enzyme hydrolyses phosphatidylinositol 3,4-bisphosphate and also has lesser activity against soluble analogues of this li...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.250476397

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
97
Issue:
25
Pages:
13696-13701
Publication date:
2000-12-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:22d6f07c-da40-466c-90d8-0154807f0b33
Source identifiers:
31782
Local pid:
pubs:31782

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