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Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

Abstract:

To accelerate progress in the development of therapeutics for protozoan parasitic diseases, we are studying enzymes active in co- and post-translational protein modification that are already the focus of drug development in other eukaryotic systems. Inhibitors of the protein farnesyltransferases (PFT) are well-established antitumour agents of low cytotoxicity and known pharmokinetic properties, while inhibitors of N-myristoyl transferase show both selectivity and specificity in the treatment ...

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Publication status:
Published

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Authors


Van Voorhis, WC More by this author
Buckner, FS More by this author
Yokoyama, K More by this author
Eastman, R More by this author
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Journal:
Molecular and biochemical parasitology
Volume:
126
Issue:
2
Pages:
155-163
Publication date:
2003-02-05
DOI:
EISSN:
1872-9428
ISSN:
0166-6851
URN:
uuid:22d68146-e7a6-4054-9940-c7087edd90ce
Source identifiers:
72704
Local pid:
pubs:72704

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