Thesis icon

Thesis

The role of Foxp3+ regulatory T-cells in transplant tolerance

Abstract:

A major conceptual shift in immunology has been the recent discovery of regulatory T-cells (Treg), of which CD4+Foxp3+ cells are already known to be essential to self-tolerance. Their role in transplant tolerance remains unproven due to the absence of a natural cell surface marker by which they can be manipulated in vivo. A transgenic B6.Foxp3hCD2 mouse was created to express an artificial GPI-anchored human CD2/CD52 surface fusion protein under the control of the Foxp3 promoter. Monoclona...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Institution:
University of Oxford
Research group:
TIG
Oxford college:
Trinity College
Department:
Medical Sciences Division - Pathology

Contributors

Role:
Supervisor
More from this funder
Funding agency for:
Adrian Reginald Kendal
Publication date:
2011
Type of award:
DPhil
Level of award:
Doctoral

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP