Journal article icon

Journal article

Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.

Abstract:

Epithelial cell migration is crucial for the development and regeneration of epithelial tissues. Aberrant regulation of epithelial cell migration has a major role in pathological processes such as the development of cancer metastasis and tissue fibrosis. Here, we report that in response to factors that promote cell motility, the Rap guanine exchange factor RAPGEF2 is rapidly phosphorylated by I-kappa-B-kinase-β and casein kinase-1α and consequently degraded by the proteasome via the SCF(βTrCP...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Journal:
Developmental cell More from this journal
Volume:
27
Issue:
5
Pages:
574-585
Publication date:
2013-12-01
DOI:
EISSN:
1878-1551
ISSN:
1534-5807

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP