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A new TB vaccine, MVA85A, induces durable antigen-specific responses 14 months after vaccination in African infants

Abstract:

This study aimed to evaluate the durability of the immunogenicity of MVA85A beyond infancy. Participants in an immunogenicity study of MVA85A administered at age of 4 months had additional evaluation 14 months after initial vaccination for IFN-γ ELISPOT responses to Ag85A peptide and ESAT6/CFP-10 and tuberculin skin test (TST).112 children participated in this study. The anthropometry, biochemical and haematological safety profile were similar between the MVA85A recipients and controls. MVA85...

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Authors


Odutola, AA More by this author
Owolabi, OA More by this author
Owiafe, PK More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Journal:
Vaccine
Volume:
30
Issue:
38
Pages:
5591-5594
Publication date:
2012-08-17
DOI:
EISSN:
1873-2518
ISSN:
0264-410X
URN:
uuid:22b7f2ce-8d6c-48e6-88f4-57e008f6bf18
Source identifiers:
348814
Local pid:
pubs:348814

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