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Journal article

Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo.

Abstract:

The lack of cell-mediated (Th1-like) immunity that is often associated with strong humoral immune responses is thought to be due in part to the inhibition of Th1 effector function by the Th2-derived cytokine interleukin-10 (IL-10). This hypothesis, however, is based entirely on results from in vitro studies, wherein IL-10 has been shown to inhibit Th1 cytokine synthesis. In this study we have compared the regulatory effects of both IL-4 and IL-10 on the development of a more complex Th1 effec...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830231147

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Coffman, RL More by this author
Journal:
European journal of immunology
Volume:
23
Issue:
11
Pages:
3043-3049
Publication date:
1993-11-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:22b2b664-7d32-4e8f-8a02-906b7dd546f7
Source identifiers:
31226
Local pid:
pubs:31226

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