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Systematic analysis of human protein complexes identifies chromosome segregation proteins.

Abstract:

Chromosome segregation and cell division are essential, highly ordered processes that depend on numerous protein complexes. Results from recent RNA interference screens indicate that the identity and composition of these protein complexes is incompletely understood. Using gene tagging on bacterial artificial chromosomes, protein localization, and tandem-affinity purification-mass spectrometry, the MitoCheck consortium has analyzed about 100 human protein complexes, many of which had not or ha...

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Publication status:
Published

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Publisher copy:
10.1126/science.1181348

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Journal:
Science (New York, N.Y.) More from this journal
Volume:
328
Issue:
5978
Pages:
593-599
Publication date:
2010-04-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075

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