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The candidate TB vaccine, MVA85A, induces highly durable Th1 responses.

Abstract:

BACKGROUND: Vaccination against tuberculosis (TB) should provide long-term protective immunity against Mycobacterium tuberculosis (M.tb). The current TB vaccine, Bacille Calmette-Guerin (BCG), protects against disseminated childhood TB, but protection against lung TB in adolescents and adults is variable and mostly poor. One potential reason for the limited durability of protection may be waning of immunity through gradual attrition of BCG-induced T cells. We determined if a MVA85A viral-vect...

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Publication status:
Published

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Journal:
PloS one More from this journal
Volume:
9
Issue:
2
Pages:
e87340
Publication date:
2014-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203

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