Journal article icon

Journal article

Activation and in vivo evolution of the MAIT cell transcriptome in mice and humans reveals tissue repair functionality

Abstract:

Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer+ cells derived from either human blood or murine lungs, we define the basic transcriptome of an activated MAIT cell in both species and demonstrate how this profile changes during the resolution of infection and during reinfection. We observe strong similarities betw...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1016/j.celrep.2019.07.039

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0003-0699-2373
More from this funder
Name:
Wellcome Trust
Grant:
104553/A/14/Z
Publisher:
Elsevier
Journal:
Cell Reports More from this journal
Volume:
28
Issue:
12
Pages:
3249-3262.e5
Publication date:
2019-09-17
Acceptance date:
2019-07-12
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Keywords:
Pubs id:
pubs:1025542
UUID:
uuid:22862174-cabe-4aff-9154-ab947fce8697
Local pid:
pubs:1025542
Source identifiers:
1025542
Deposit date:
2019-07-02

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP