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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

Abstract:

Protein kinase casein kinase 2 (CK2) is a serine/threonine kinase with evidence of implication in growth dysregulation and apoptosis resistance, making it a relevant target for cancer therapy. Several CK2 inhibitors have been developed showing variable efficiency, emphasizing the need to expand the chemical diversity of those inhibitors. We report the identification and characterization of 2,8-difurandicarboxylic acid derivatives as a new class of nanomolar ATP-competitive inhibitors. Selecti...

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Publication status:
Published

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Publisher copy:
10.1096/fj.09-143743

Authors


López-Ramos, M More by this author
Prudent, R More by this author
Moucadel, V More by this author
Sautel, CF More by this author
Barette, C More by this author
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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
24
Issue:
9
Pages:
3171-3185
Publication date:
2010-09-05
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
URN:
uuid:228498b5-335a-4878-8c34-b718b221f843
Source identifiers:
53313
Local pid:
pubs:53313

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