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Denosumab and bisphosphonates: different mechanisms of action and effects.

Abstract:

To treat systemic bone loss as in osteoporosis and/or focal osteolysis as in rheumatoid arthritis or periodontal disease, most approaches target the osteoclasts, the cells that resorb bone. Bisphosphonates are currently the most widely used antiresorptive therapies. They act by binding the mineral component of bone and interfere with the action of osteoclasts. The nitrogen-containing bisphosphonates, such as alendronate, act as inhibitors of farnesyl-pyrophosphate synthase, which leads to inh...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2010.11.020
Journal:
Bone More from this journal
Volume:
48
Issue:
4
Pages:
677-692
Publication date:
2011-04-01
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
Language:
English
Keywords:
Pubs id:
pubs:110418
UUID:
uuid:2282dcbc-3633-4de0-95cf-c373792c495e
Local pid:
pubs:110418
Source identifiers:
110418
Deposit date:
2013-11-16

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