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Thesis

Intracellular trafficking of the invasion-promoting cell surface proteinase MT1-MMP

Abstract:

Membrane type-1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that has been shown to promote the progression of different diseases, including rheumatoid arthritis (RA) and cancer, by enhancing cellular invasion. MT1-MMP promotes cellular invasion by degrading pericellular extracellular matrix (ECM) at the leading edge of migrating cells. MT1-MMP has been shown to localise to various motility-associated structures, including lamellipodia, filopodia, invadopodia, and p...

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Division:
MSD
Role:
Author
ORCID:
0000-0002-6612-7034

Contributors

Role:
Supervisor
ORCID:
0000-0003-4983-6389
Role:
Supervisor
ORCID:
0000-0002-2128-2823
Role:
Examiner
ORCID:
0000-0002-4994-2264
Role:
Examiner
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Grant:
Programme:
Kennedy Trust Prize Studentship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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