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Journal article

The mitochondrion-lysosome axis in adaptive and innate immunity: effect of lupus regulator peptide P140 on mitochondria autophagy and NETosis

Abstract:

Mitochondria deserve special attention as sensors of cellular energy homeostasis and metabolic state. Moreover, mitochondria integrate intra- and extra-cellular signals to determine appropriate cellular responses that range from proliferation to cell death. In autoimmunity, as in other inflammatory chronic disorders, the metabolism of immune cells may be extensively remodeled, perturbing sensitive tolerogenic mechanisms. Here, we examine the distribution and effects of the therapeutic 21-mer ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fimmu.2018.02158

Authors


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ORCID:
0000-0002-5354-6096
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Women’s & Reproductive Health
Subgroup:
Women's & Reproductive Health
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French Centre National de la Recherche Scientifique More from this funder
Initiative of Excellence More from this funder
Strasbourg University More from this funder
Région Alsace More from this funder
Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
9
Pages:
Article: 2158
Publication date:
2018-09-26
Acceptance date:
2018-08-31
DOI:
ISSN:
1664-3224
Pubs id:
pubs:925590
URN:
uri:226a9c89-ef62-497a-811b-60cb4beb9474
UUID:
uuid:226a9c89-ef62-497a-811b-60cb4beb9474
Local pid:
pubs:925590

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