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Limited protective effect of the CCR5Delta32/CCR5Delta32 genotype on human immunodeficiency virus infection incidence in a cohort of patients with hemophilia and selection for genotypic X4 virus.

Abstract:

The relationship among CCR5 genotype, cytomegalovirus infection, and disease progression and death was studied among 159 human immunodeficiency virus (HIV)-infected patients with hemophilia. One patient (0.6%) had the CCR5Delta32/CCR5Delta32 genotype (which occurs in approximately 2% of the Scandinavian population) and a rapid disease course. His HIV V3 region contained genotypic features attributable to X4 virus and resembled functionally verified X4 virus and virus from patients treated wit...

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Publication status:
Published

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Publisher copy:
10.1086/345881

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Journal:
The Journal of infectious diseases
Volume:
187
Issue:
2
Pages:
215-225
Publication date:
2003-01-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:226a1578-ccee-4c3b-bc21-279925be70cf
Source identifiers:
67885
Local pid:
pubs:67885

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