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Dissection of cell cycle-dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling.

Abstract:

DNA methyltransferase 1 (Dnmt1) reestablishes methylation of hemimethylated CpG sites generated during DNA replication in mammalian cells. Two subdomains, the proliferating cell nuclear antigen (PCNA)-binding domain (PBD) and the targeting sequence (TS) domain, target Dnmt1 to the replication sites in S phase. We aimed to dissect the details of the cell cycle-dependent coordinated activity of both domains. To that end, we combined super-resolution 3D-structured illumination microscopy and flu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
Deutsche Forschungsgemeinschaft
Funding agency for:
Schermelleh, L
Grant:
SFB 684
Publisher:
Oxford University Press
Journal:
Nucleic acids research More from this journal
Volume:
41
Issue:
9
Pages:
4860-4876
Publication date:
2013-05-01
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
Language:
English
Keywords:
Pubs id:
pubs:391049
UUID:
uuid:225bf461-d9a2-4d46-8b63-5ff46da04761
Local pid:
pubs:391049
Source identifiers:
391049
Deposit date:
2013-09-26

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