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Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors

Abstract:

During pancreatic development, proliferating pancreatic progenitors activate the proendocrine transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differentiate into islet cells. The mechanisms that direct robust NEUROG3 expression within a subset of progenitor cells control the size of the endocrine population. Here we demonstrate that NEUROG3 is phosphorylated within the nucleus on serine 183, which catalyzes its hyperphosphorylation and proteosomal degradation. During prog...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Name:
National Institutes of Health
Grant:
R01 DK021344
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Name:
National Science and Engineering Research Council of Canada
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Name:
University of British Columbia
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Name:
Canadian Institutes of Health Research
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Name:
British Columbia Children’s Hospital Research Institute
Publisher:
Elsevier
Journal:
Developmental Cell More from this journal
Volume:
41
Issue:
2
Pages:
129-142.e6
Publication date:
2017-02-24
Acceptance date:
2017-02-09
DOI:
EISSN:
1878-1551
ISSN:
1534-5807
Pmid:
28441528
Language:
English
Keywords:
Pubs id:
pubs:831165
UUID:
uuid:22539420-7354-4b49-9159-8d3e54b05dc4
Local pid:
pubs:831165
Source identifiers:
831165
Deposit date:
2018-06-22

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