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Study protocol: A multi-centre, double blind, randomised, placebo-controlled, parallel group, phase II trial (RIDD) to determine the efficacy of intra-nodular injection of anti-TNF to control disease progression in early Dupuytren’s disease, with an embedded dose response study

Abstract:

Dupuytren’s disease is a common fibrotic condition of the hand affecting 4% of the population and causes the fingers to curl irreversibly into the palm. It has a strong familial tendency, there is no approved treatment for early stage disease, and patients with established digital contractures are most commonly treated by surgery. This is associated with prolonged recovery, and less invasive techniques have high recurrence rates.The myofibroblasts, the cells responsible for the excessive matr...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.12688/wellcomeopenres.11466.2

Authors


Nanchahal, J More by this author
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Department:
Oxford, MSD, NDORMS, KIR
Swettenham, J More by this author
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Funding agency for:
Nanchahal, J
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Funding agency for:
Ball, C
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Funding agency for:
Swettenham, J
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Funding agency for:
Dritsaki, M
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Funding agency for:
Taylor, P
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Publisher:
F1000Research Publisher's website
Journal:
Wellcome Open Research Journal website
Volume:
2
Issue:
37
Pages:
1-28
Publication date:
2017-11-16
Acceptance date:
2017-11-16
DOI:
ISSN:
2398-502X
Pubs id:
pubs:698596
URN:
uri:2251669b-5e61-42e5-97d1-592da8a0ccc3
UUID:
uuid:2251669b-5e61-42e5-97d1-592da8a0ccc3
Local pid:
pubs:698596

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