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Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase

Abstract:

Prenylated indole alkaloids such as the calmodulin-inhibitory malbrancheamides and anthelmintic paraherquamides possess great structural diversity and pharmaceutical utility. Here, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approaches. These include a biomimetic total synthesis to access the natural alkaloid and biosynthetic intermediates in racemic form and in vitro enzymatic reconstitution to provide access to the natural an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41557-019-0326-6

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Role:
Author
ORCID:
0000-0002-3110-9450
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Role:
Author
ORCID:
0000-0002-9623-7779
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Role:
Author
ORCID:
0000-0002-7826-6453
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Name:
National Institutes of Health
Funder identifier:
http://dx.doi.org/10.13039/100000002
Publisher:
Nature Research
Journal:
Nature Chemistry More from this journal
Volume:
11
Issue:
November 2019
Pages:
972-980
Publication date:
2019-09-23
Acceptance date:
2019-08-05
DOI:
EISSN:
1755-4349
ISSN:
1755-4330
Pmid:
31548667
Language:
English
Keywords:
Pubs id:
1060186
Local pid:
pubs:1060186
Deposit date:
2020-07-30

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