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IFITM3, TLR3, and CD55 gene SNPs and cumulative genetic risks for severe outcomes in Chinese patients with H7N9/H1N1pdm09 influenza

Abstract:

Background. We examined associations between single-nucleotide polymorphisms (SNPs) of IFITM3, TLR3, and CD55 genes and influenza clinical outcomes in Chinese.

Methods. A multicenter study was conducted on 275 adult cases of avian (H7N9) and pandemic (H1N1pdm09) influenza. Host DNA was extracted from diagnostic respiratory samples; IFITM3 rs12252, TLR3 rs5743313, CD55 rs2564978, and TLR4 rs4986790/4986791 wer...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/infdis/jix235

Authors


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Name:
Health and Medical Research Fund, Hong Kong SAR Government
Grant:
RRG-09
Publisher:
Oxford University Press
Journal:
Journal of Infectious Diseases More from this journal
Volume:
216
Issue:
1
Pages:
97-104
Publication date:
2017-05-16
Acceptance date:
2017-05-11
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
Language:
English
Keywords:
Pubs id:
pubs:695819
UUID:
uuid:2250ae57-bc8f-4390-9443-5a9e96955ee4
Local pid:
pubs:695819
Source identifiers:
695819
Deposit date:
2017-07-17

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