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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

Abstract:

To identify novel susceptibility loci for Crohn disease (CD), we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of disease association with p-values between 10−6 and 10−9. Two of these (IL23R on Chromosome 1 and CARD15 on Chromosome 16) correspond to genes previously reported to be associated with CD. In addition, a 250-kb region of Chromosome 5p13.1 was found to con...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.0030058

Authors


Libioulle, C More by this author
Hansoul, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Région Wallonne More from this funder
Communauté Française de Belgique More from this funder
Genefunc and Biomagnet pôles d'attraction interuniversitaires More from this funder
University of Liège More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
3
Issue:
4
Pages:
e58-e58
Publication date:
2007
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
URN:
uuid:224eb7e7-24eb-4dac-8153-8e0f5b6aed87
Source identifiers:
575353
Local pid:
pubs:575353

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