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Mathematical modelling of blood-brain barrier failure and edema

Abstract:

Injuries such as traumatic brain injury and stroke can result in increased blood–brain barrier permeability. This increase may lead to water accumulation in the brain tissue resulting in vasogenic edema. Although the initial injury may be localised, the resulting edema causes mechanical damage and compression of the vasculature beyond the original injury site. We employ a biphasic mixture model to investigate the consequences of blood–brain barrier permeability changes within a region of brai...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/imammb/dqw009

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Mathematical Institute
Role:
Author
Publisher:
Oxford University Press
Journal:
Mathematical Medicine and Biology More from this journal
Publication date:
2016-06-15
Acceptance date:
2016-04-29
DOI:
EISSN:
1477-8602
ISSN:
1477-8599
Keywords:
Pubs id:
pubs:619161
UUID:
uuid:224d8108-7e9e-49d9-b2d7-42e9a827d2fb
Local pid:
pubs:619161
Source identifiers:
619161
Deposit date:
2016-05-03

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