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Journal article

Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual.

Abstract:

With the goal of examining the functional diversity of human immunodeficiency virus type 1 (HIV-1) env genes within the peripheral blood mononuclear cells of an asymptomatic individual, we substituted four complete env genes into the replication-competent NL4-3 provirus. Despite encoding full-length open reading frames for gp120 and gp41 and the second coding exon of tat and rev, each chimera was replication defective. Site-directed mutagenesis of codon 78 in the Rev activation domain (from a...

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Journal:
Journal of virology More from this journal
Volume:
69
Issue:
9
Pages:
5743-5753
Publication date:
1995-09-01
EISSN:
1098-5514
ISSN:
0022-538X

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