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Caloric restriction attenuates age-related changes of DNA methyltransferase 3a in mouse hippocampus.

Abstract:

Recent studies have suggested that DNA methylation is implicated in age-related changes in gene expression as well as in cognition. DNA methyltransferase 3a (Dnmt3a), which catalyzes DNA methylation, is essential for memory formation and underlying changes in neuronal and synaptic plasticity. Because caloric restriction (CR) and upregulation of antioxidants have been suggested as strategies to attenuate age-related alterations in the brain, we hypothesized that both a diet restricted in calor...

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Publisher copy:
10.1016/j.bbi.2010.11.016

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
van den Hove, DL More by this author
Dela Cruz, J More by this author
Lemmens, MA More by this author
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Journal:
Brain, behavior, and immunity
Volume:
25
Issue:
4
Pages:
616-623
Publication date:
2011-05-05
DOI:
EISSN:
1090-2139
ISSN:
0889-1591
URN:
uuid:22455e85-ca8d-40cd-a22d-387cc49b739c
Source identifiers:
456148
Local pid:
pubs:456148

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