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Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity.

Abstract:

Substantial protection can be provided against the pre-erythrocytic stages of malaria by vaccination first with an adenoviral and then with an modified vaccinia virus Ankara (MVA) poxviral vector encoding the same ME.TRAP transgene. We investigated whether the two vaccine components adenovirus (Ad) and MVA could be coinjected as a mixture to enhance protection against malaria. A single-shot mixture at specific ratios of Ad and MVA (Ad+MVA) enhanced CD8(+) T cell-dependant protection of mice a...

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Publication status:
Published

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Publisher copy:
10.1038/mt.2012.25

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
Rollier, CS More by this author
Milicic, A More by this author
Cottingham, MG More by this author
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Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
20
Issue:
8
Pages:
1633-1647
Publication date:
2012-08-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:2237488d-da77-414d-8692-c87b2da3d83f
Source identifiers:
311918
Local pid:
pubs:311918

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