Journal article icon

Journal article

Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity.

Abstract:

Substantial protection can be provided against the pre-erythrocytic stages of malaria by vaccination first with an adenoviral and then with an modified vaccinia virus Ankara (MVA) poxviral vector encoding the same ME.TRAP transgene. We investigated whether the two vaccine components adenovirus (Ad) and MVA could be coinjected as a mixture to enhance protection against malaria. A single-shot mixture at specific ratios of Ad and MVA (Ad+MVA) enhanced CD8(+) T cell-dependant protection of mice a...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/mt.2012.25

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Role:
Author
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy More from this journal
Volume:
20
Issue:
8
Pages:
1633-1647
Publication date:
2012-08-01
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
Language:
English
Keywords:
Pubs id:
pubs:311918
UUID:
uuid:2237488d-da77-414d-8692-c87b2da3d83f
Local pid:
pubs:311918
Source identifiers:
311918
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP