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Journal article

Redundancy and evolution of GATA factor requirements in development of the myocardium.

Abstract:

The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family for the first time. Using morpholinos in both Xenopus and zebrafish embryos, we show that GATA4 knockdown, for example, only affects cardiac marker expression in the absence of e...

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Publication status:
Published

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Publisher copy:
10.1016/j.ydbio.2007.08.018

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, BHF Centre of Research Excellence
Role:
Author
Journal:
Developmental biology
Volume:
311
Issue:
2
Pages:
623-635
Publication date:
2007-11-05
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
URN:
uuid:2232c2f1-c7b2-45ac-8798-c7f6c1a6c850
Source identifiers:
106458
Local pid:
pubs:106458

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