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Journal article

Capture-C reveals preformed chromatin interactions between HIF-binding sites and distant promoters

Abstract:

Hypoxia inducible factor (HIF) directs an extensive transcripti onal cascade that transduces numerous adaptive responses to hypoxia. Pan-genomic analyses, using chromatin immunoprecipitation and transcript profiling, h ave revealed large numbers of HIF-binding sites that are generally associate d with hypoxia- inducible transcripts, even over long chromosomal distances. Ho wever, these studies do not define the specific targets of HIF-binding sites and do not reveal how induction of...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.15252/embr.201642198

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More from this funder
Name:
Wellcome Trust
Grant:
WT091857MA
More from this funder
Name:
Cancer Research UK
Grant:
A16016
More from this funder
Name:
Ministry of High Education for Saudi Arabia
More from this funder
Name:
Deanship of Scientific Research
Publisher:
EMBO Press
Journal:
EMBO Reports More from this journal
Volume:
17
Issue:
10
Pages:
1410-1421
Publication date:
2016-08-09
Acceptance date:
2016-07-15
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Keywords:
Pubs id:
pubs:634339
UUID:
uuid:22255408-a3eb-4133-b95b-e99446388c8d
Local pid:
pubs:634339
Source identifiers:
634339
Deposit date:
2016-07-15

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