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Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

Abstract:

CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that has emerged as a key regulator of neurite outgrowth, vesicle trafficking and cancer cell proliferation. CDK16 is activated through binding to cyclin Y via a phosphorylation-dependent 14-3-3 interaction and has an unique consensus substrate phosphorylation motif compared to conventional CDKs. To elucidate the structure and inhibitor binding propert...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1042/BCJ20160941

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Trinity College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
More from this funder
Name:
Ontario Genomics Institute
Grant:
OGI-055
More from this funder
Name:
Ontario Ministry of Economic Development and Innovation
More from this funder
Name:
Novartis Research Foundation
Publisher:
Portland Press
Journal:
Biochemical Journal More from this journal
Volume:
474
Issue:
5
Pages:
699-713
Publication date:
2017-01-01
Acceptance date:
2017-01-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
Language:
English
Keywords:
Pubs id:
pubs:671510
UUID:
uuid:22221363-0ab0-4271-be79-21a6fb8b6817
Local pid:
pubs:671510
Deposit date:
2017-01-24

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