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Interleukin-32 promotes osteoclast differentiation but not osteoclast activation

Abstract:

Background: Interleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-γ. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently reported its effect on the osteoclastogenesis process remains unclear. Methodology/principal findings: In the present study, we have shown that IL-32 was a potent modulator of osteoclastogenesis in vitro, whereby it promoted the differentiation of o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Medical Sciences Division - Orthopaedic Surgery
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Orthopaedic Surgery
Role:
Author
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
4
Issue:
1
Article number:
e4173
Publication date:
2009-01-01
DOI:
EISSN:
1932-6203
Language:
English
Subjects:
UUID:
uuid:221e19e4-b392-4d39-8968-8831c17e1c6f
Local pid:
ora:4277
Deposit date:
2010-10-18

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