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How can controlled human infection models accelerate clinical development and policy pathways for vaccines against Shigella?

Abstract:

Controlled Human Infection Models (CHIMs) now exist for several infectious diseases. CHIMs offer significant insight into disease pathogenesis, as well the potential to rapidly test clinical proof-of-concept of vaccine candidates. The application of CHIMs to identify a correlate of protection that may reduce the sample size of, or obviate the need for clinical efficacy studies to achieve licensure is of considerable interest to vaccine developers and public health stakeholders. This topic was...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Elsevier
Journal:
Vaccine More from this journal
Volume:
37
Issue:
34
Pages:
4778-4783
Publication date:
2019-07-26
Acceptance date:
2019-03-19
DOI:
ISSN:
0264-410X and 1873-2518
Pmid:
31358238
Language:
English
Keywords:
Pubs id:
pubs:995294
UUID:
uuid:221b3ebb-7f30-4f4c-ac04-234f29137f15
Local pid:
pubs:995294
Source identifiers:
995294
Deposit date:
2019-09-05

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