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Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression.

Abstract:

Tumour-associated angiogenesis is partly regulated by the hypoxia-inducible factor (HIF) pathway. Endocrine tumours are highly vascularised and the molecular mechanisms of their angiogenesis are not fully delineated. The aim of this study is to evaluate angiogenesis and expression of HIF-related molecules in a series of patients with pancreatic endocrine tumours (PETs). The expression of vascular endothelial growth factor (VEGF), HIF-1alpha, HIF-2alpha and carbonic anhydrase 9 (CA9) was exami...

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Publication status:
Published

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Publisher copy:
10.1038/sj.bjc.6602245

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Journal:
British journal of cancer More from this journal
Volume:
92
Issue:
1
Pages:
94-101
Publication date:
2005-01-01
DOI:
EISSN:
1532-1827
ISSN:
0007-0920

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