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A scoping review of the problems and solutions associated with contamination in trials of complex interventions in mental health

Abstract:

Background In a randomised controlled trial, contamination is defined as the receipt of active intervention amongst participants in the control arm. This review assessed the processes leading to contamination, its typical quantity, methods used to mitigate it, and impact of use of cluster randomisation to prevent it on study findings in trials of complex interventions in mental health.

Methods This is a scoping review of trial design approaches and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12874-018-0646-z

Authors


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Role:
Author
ORCID:
0000-0002-5138-3166
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
ORCID:
0000-0001-6810-2845
Publisher:
BioMed Central
Journal:
BMC Medical Research Methodology More from this journal
Volume:
19
Article number:
4
Publication date:
2019-01-07
Acceptance date:
2018-12-17
DOI:
EISSN:
1471-2288
Language:
English
Keywords:
Pubs id:
pubs:1005916
UUID:
uuid:22055808-05dd-44dd-bf1c-117efefb483b
Local pid:
pubs:1005916
Source identifiers:
1005916
Deposit date:
2019-06-04

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