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Thesis

Investigating mechanisms driving fibrosis in pathological rotator cuff tendons

Abstract:

Shoulder pain is common, often caused by rotator cuff inflammation and usually heals by fibrotic repair. The fibrotic signature associated with the resolution of inflammation is well documented in a number of human tissue pathologies, but not tendon. TGFβ and its associated superfamily are implicated as key drivers of fibrosis, and modulate extracellular matrix homeostasis. The aim of this thesis was principally to investigate the TGFβ axis in healthy and pathological tendons, and to study...

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Division:
MSD
Role:
Author

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Supervisor
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Supervisor
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Name:
Nuffield Trust
Grant:
Girdlestone scholarship
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford
UUID:
uuid:21f7f117-8222-4682-9255-186a4ab697c5
Deposit date:
2016-12-07

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