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Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism.

Abstract:

Ryanodine receptor (RyR) activation by cyclic ADP-ribose (cADPR) is followed by homologous desensitization. Though poorly understood, this "switching off" process has provided a key experimental tool for determining the pathway through which cADPR mediates Ca(2+) release. Moreover, desensitization is likely to play an important role in shaping the complexities of Ca(2+) signaling involving cADPR, for example, localized release events and propagated waves. Using the sea urchin egg, we unmask a...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
Journal:
Current biology : CB More from this journal
Volume:
12
Issue:
23
Pages:
2018-2022
Publication date:
2002-12-01
DOI:
EISSN:
1879-0445
ISSN:
0960-9822
Language:
English
Keywords:
Pubs id:
pubs:106164
UUID:
uuid:21f7caec-45db-4bc0-bf12-7dcdbae4d355
Local pid:
pubs:106164
Source identifiers:
106164
Deposit date:
2012-12-19

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