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Vi-specific serological correlates of protection for typhoid fever

Abstract:

Typhoid Vi vaccines have been shown to be efficacious in children living in endemic regions; however, a widely accepted correlate of protection remains to be established. We applied a systems serology approach to identify Vi-specific serological correlates of protection using samples obtained from participants enrolled in an experimental controlled human infection study. Participants were vaccinated with Vi-tetanus toxoid conjugate (Vi-TT) or unconjugated Vi-polysaccharide (Vi-PS) vaccines an...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1084/jem.20201116

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
More by this author
Role:
Author
ORCID:
0000-0001-8904-9334
More by this author
Role:
Author
ORCID:
0000-0002-1671-9744
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Name:
Bill & Melinda Gates Foundation
Grant:
OPP1084259
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Name:
Oxford Biomedical Research Centre
Grant:
BZR01462
More from this funder
Name:
National Institute for Health Research
Grant:
NF-SI-0617-10036
Publisher:
Rockefeller University Press
Journal:
Journal of Experimental Medicine More from this journal
Volume:
218
Issue:
2
Article number:
e20201116
Publication date:
2020-11-12
Acceptance date:
2020-10-08
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Pmid:
33180929
Language:
English
Keywords:
Pubs id:
1147055
Local pid:
pubs:1147055
Deposit date:
2020-12-01

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