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A pragmatic group sequential, placebo-controlled, randomised trial to determine the effectiveness of glyceryl trinitrate for retained placenta (GOT-IT): a study protocol

Abstract:

A retained placenta is diagnosed when the placenta is not delivered following delivery of the baby. It is a major cause of postpartum haemorrhage and treated by the operative procedure of manual removal of placenta (MROP).The aim of this pragmatic, randomised, placebo-controlled, double-blind UK-wide trial, with an internal pilot and nested qualitative research to adjust strategies to refine delivery of the main trial, is to determine whether sublingual glyceryl trinitrate (GTN) is (or is not...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1136/bmjopen-2017-017134

Authors


Denison, FC More by this author
Norman, JE More by this author
Scotland, G More by this author
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Grant:
Health Technology Assessment (HTA) programme (Project number 12/29/01)
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
7
Issue:
9
Pages:
Article: e017134
Publication date:
2017-09-18
DOI:
ISSN:
2044-6055
Pubs id:
pubs:730229
URN:
uri:21e2e342-913b-4b46-9e72-ab1280b6db61
UUID:
uuid:21e2e342-913b-4b46-9e72-ab1280b6db61
Local pid:
pubs:730229

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