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Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat.

Abstract:

This study aimed to evaluate the pharmacokinetic properties of piperaquine in the rat after intravenous and oral administration, and to identify and characterize the main piperaquine metabolites in rat plasma, urine, faeces and bile after intravenous administration. Male Sprague-Dawley rats were administered piperaquine as an emulsion orally or as a short-term intravenous infusion. Venous blood for pharmacokinetic evaluation was frequently withdrawn up to 90 h after dose. Urine, bile and faec...

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Publication status:
Published

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Publisher copy:
10.1002/jps.21226

Authors


Tarning, J More by this author
Lindegardh, N More by this author
Sandberg, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
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Journal:
Journal of pharmaceutical sciences
Volume:
97
Issue:
8
Pages:
3400-3410
Publication date:
2008-08-05
DOI:
EISSN:
1520-6017
ISSN:
0022-3549
URN:
uuid:21d849ec-d985-41bb-961f-b1da9a8edd4b
Source identifiers:
21067
Local pid:
pubs:21067

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