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Efficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activity.

Abstract:

Integration of proviral DNA into the host cell genome is a characteristic feature of the retroviral life cycle. This process involves coordinate DNA strand break formation and rejoining reactions. The full details of the integration process are not yet fully understood. However, the endonuclease and DNA strand-joining activities of the virus-encoded integrase protein (IN) are thought to act in concert with other, as-yet-unidentified, endogenous nuclear components which are involved in the DNA...

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Publication status:
Published

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Journal:
Journal of virology More from this journal
Volume:
70
Issue:
6
Pages:
3992-4000
Publication date:
1996-06-01
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:466400
UUID:
uuid:21d0e921-23a4-4969-b971-e0b70e4e501e
Local pid:
pubs:466400
Source identifiers:
466400
Deposit date:
2014-06-18

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